12 Guidelines on Prostate Cancer European Association of Urology 2007 “…However, it is worth pointing out that increasing comorbidity with increasing age substantially decreases the actual risk of dying from localized CaP in men over the age of 70 years…”T2 CaP“…However, in an older patient or one with clinically significant co-existing conditions, radiation therapy could be the best option…”Walsh, NEJM 2002
13 Τι είδους ακτινοθεραπεία ; Βραχυθεραπεία3D – CRT ή IMRT ± βραχυθεραπεία± 6 mo ADTD’Amico et al. JAMA 2004↑ % επιβίωσης & επιβίωσης χωρίς ADT διάσωσης↓ θνησιμότητας από CaP
18 RT + ADTAfter a median follow-up of 4.5 years, patients randomized to receive 3D-CRT plus ADT had a significantly higher survival rate (p = 0.04), lower CaP-specific mortality rate (p = 0.02), and a higher survival rate free of salvage ADT (p = 0.002)D’Amico A, Manola J, Loffredo M, Renshaw AA, DellaCroce A, Kantoff PW. 6-month androgen suppression plus radiation therapy vs radiation therapy alone for patients with clinically localized prostate cancer; a randomized controlled trial. JAMA 2004;292(7):
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